Legg-Calve-Perthes Disease: A Case Study

When A.L. was 11 years old, he complained of pain in his left hip. The pain subsided, but a week and a half later, A.L. came home crying and barely able to walk. The pain in his hip had become “excruciating.”

Positive Preliminary Data on CRISPR Treatment for Blood Diseases

A collaborative team of researchers, including Dr. Stephan Grupp, recently presented preliminary data showing that a CRISPR-based gene-editing therapy for inherited blood disorders is safe and effective.

Passing the Sniff Test: CHOP Researchers Identify SARS-CoV-2 Breath Biomarkers in Children

CHOP researchers have identified six biomarkers in the breath of children with COVID-19, laying the groundwork for a potential breathalyzer test.

Case Study: Treating Complex Pancreatitis in Youth

Read a case study about a patient treated by physicians from the Pancreatic Disorders Program.

Study Shows Benefit of Blinatumomab for High-Risk Relapsed B-ALL

A new study involving CHOP researchers show blinatumomab is less toxic and as good or better than chemotherapy for high-risk relapsed B-ALL.

Unexpected Consequence of the Pandemic: MIS-C-Related Cardiac Issues

In May 2020, the U.S. Centers for Disease Control and Prevention (CDC) defined multi-system inflammatory syndrome in children (MIS-C), which was the diagnosis in this case.

CHOP Researchers Find Effective Combination of Therapies for Managing Mitochondrial Disease

Study is first to demonstrate how one specific combinational therapy may provide measurable benefits to patients with mitochondrial respiratory chain disorders, which currently lack FDA-approved therapies.

Experts at Children’s Hospital of Philadelphia Describe Types of Rashes Associated with MIS-C

CHOP researchers describe different types of rashes they have seen in patients diagnosed with the COVID-19-related inflammatory syndrome.

CHOP Researchers Find NTRK Fusions More Common than Expected in Pediatric Tumors

CHOP researchers have found that NTRK fusions are more common than expected in pediatric tumors, which could lead to better screening and treatment.

CHOP Researchers Characterize Shared Pathways in Epilepsy and Autism

In a new study, CHOP researchers integrate data regarding how the conditions present clinically with data on protein-protein interactions.